03 Gm negative cocci
- pink handcuff: Gram negative diplococci
- blue ring: Oxidase positive
- ferments glucose. Meningiditis also ferments maltose
- Vice City Private Investigator: Growth on VPN agar
- Thayer Martin: Alternate name for VPN agar
- Chocolate bar: Growth on chocolate agar
The commonly used antibiotics are vancomycin to inhibit gram-positive bacteria, colistin (i.e. polymyxin) to inhibit gram-negative bacteria (commensal Neisseria species but not N. meningitidis or N. gonorrhoeae), nystatin to inhibit yeast, and trimethoprim to inhibit the Proteus species.
- Mac: Patients with C5-C9 deficiency are unable to form MAC complex, leading to increased infections
- 5-9PM: C5-C9 deficiency
- chains: Pili demonstrate antigenic variation. Fimbriae
- card: IgA protease - cleaves IgA at hinge region
Neisseria Meningiditis
- Dorm room: Easily spread in close quarters like college dorms
- Communist flag: Sickle cell and asplenic patients at higher risk of infection
- Malt liquor: Ferments maltose in addition to glucose. Compare with neisseria gonorrhea
- plastic bags on floor: Polysaccharide capsule inhibits phagocytosis
- Q tip: Colonizes nasopharynx first. Transmitted by respiratory secretions.
- Syringe, A, C, D: Vaccine contains polysaccharide capsule
- No syringe: Type B capsule not included in vaccine
- Envelope burning: LOS envelope proteins cause inflammatory response
- Water leaking: Inflammation leads to leaky capillaries
- Electric circuit: Capillary leakage can lead to hypovolemia and shock
- Underwear with red dots: Characteristic petechial rash indicates thrombocytopenia
- Wet floor spots: Petechial rash from thrombocytopenia. Risk of DIC
- Petechial rash from thrombocytopenia. Risk of DIC
- Water house: Waterhouse-Friderichsen syndrome, characterized by hemorrhage of adrenals (adrenal insufficiency, low bp, shock, DIC)
- Ceftriaxone treatment
- Rifampin prophylaxis in close contacts
Neisseria Gonorrhea
- Red pillows in white chairs: Gram negative diplococci, facultative intracellular in PMNs
- Broken glass: not encapsulated
- chandelier: Causes Pelvic Inflammatory Disease in females
- white on table: Characteristic white purulent discharge
- Band name: Fitz Hugh Curtis Syndrome: spread of PID into peritoneum
- violin: Violin string adhesions form to capsule of liver
- covering baby's eyes: Early onset conjunctivitis in newborns
- cracked knee: Asymmetric arthritis, commonly in knee
- Ceftriaxone treatment
- clam: Chlamydia coinfection, doxycyclinen and macrolide